Avenir with FF Meta Serif in action on fifty-five.com

Under the hood

.header-1 { font-family: Avenir; font-size: 29px; font-style: normal; font-weight: normal; letter-spacing: normal; line-height: 32px; text-transform: none; color: #FF7200; }
.header-2 { font-family: MetaSerif; font-size: 36px; font-style: normal; font-weight: bold; letter-spacing: normal; line-height: 43px; text-transform: none; color: #222222; }
.content-1 { font-family: Avenir; font-size: 20px; font-style: normal; font-weight: normal; letter-spacing: normal; line-height: 32px; text-transform: none; color: #222222; }
.content-2 { font-family: Avenir; font-size: 14px; font-style: normal; font-weight: normal; letter-spacing: normal; line-height: 32px; text-transform: uppercase; color: #FF7200; }

Avenir is available from Fonts.com and MyFonts.